A Fetal Hemoglobin with Abnormal γ-Polypeptide Chains: Hemoglobin Warren

Fetal Hemoglobin with Abnormal ‘ Y . Polypeptide Chains : Hemoglobin Warren

By T. H. J. HUISMAN, A. M. Dozy, B. E. HORTON AND J. B. WILsON T HE EXISTENCE of variants of normal human fetal hemoglobin ( HbFor a2y2 ) has been suggested in different reports in the literature. Variants of fetal hemoglobin with abnormal a-polypeptide chains have been described5 ”5 and some are well characterized.’0 Only one abnormality, namely the electrophoretically fast moving hemoglobin v...

Alpha, beta and gamma hemoglobin polypeptide chains during the neonatal period with description of a fetal form of hemoglobin Da-St. Louis.

An unusual case of leukemia with high fetal hemoglobin: demonstration of abnormal hemoglobin synthesis localized in a red cell clone.

A high level of fetal hemoglobin was found in an 8-yr-old boy without any hematologic disorders except for a moderate anemia. The absence of hemoglobin abnormalities in the parents led us to suspect a latent malignant disease that, on follow-up, was confirmed to be myelomonocytic leukemia. Hemoglobin biosynthetic studies provided evidence of unbalanced synthesis of globin subunits by reticulocy...

The Abnormal Hemoglobin Syndromes

By IRwIN 1\i. WEINSTEIN, CARROLL L. SPURLING, HERMAN I’tLEIN AND THOMAS F. XECHELES I x PREVIOUS PUBLICATIONS,’ ,2 1e have reported that tagging human erythrocytes with radioactive chromium in the form of Na2Cr”O4 affords a simple, rapid and reproducible method for studying the survival of erythrocytes in normal subjects and patients with various hernatologic disturbances. By this method the on...

The Amino Acid Composition of Hemoglobin. 3. a Qualitative Method for Identifying Abnormalities of the Polypeptide Chains of Hemoglobin.

SEPARATION of the component chains of human and animal hemoglobins may be achieved by a variety of methods including chromatography on IRC-50’ using a urea gradient at pH 1.9, differential precipitation in trichloracetic acid2 and by countercurrent distribution.3 It is frequently desirable to separate and characterize the polypeptide chains of hemoglobins in small quantities as a rapid test for...